Topical Application of Thymidine Dinucleotide to Newborn Mice Reduces and Delays Development of Uv-induced Melanomas
نویسندگان
چکیده
One major risk factor for cutaneous melanoma is ultraviolet (UV) exposure. Intense intermittent UV exposure and childhood sunburn are linked epidemiologically with melanoma risk, and in mice neonatal UV exposure promotes development of cutaneous melanoma (Noonan et al., 2001; Kannan et al., 2003). Other evidence that UV contributes to melanomagenesis includes increased risk for populations with extensive intense sun exposure, as well as for fair-skinned (Fitzpatrick’s skin type I–II) individuals and patients with xeroderma pigmentosum, who repair photoproducts very poorly (Gilchrest et al., 1999; Kraemer et al., 1987).
منابع مشابه
Topical DNA oligonucleotide therapy reduces UV-induced mutations and photocarcinogenesis in hairless mice.
UV-induced DNA damage gives rise to mutations and skin cancer. We have previously reported that treatment of skin cells in vitro with thymidine dinucleotide (pTT) activates p53 and increases the ability of cells to repair subsequent UV-induced DNA damage by enhancing endogenous DNA repair capacity. Here we show that topical pTT pretreatment enhances the rate of DNA photoproduct removal, decreas...
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